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One weight loss trial demonstrated no difference between people who took those who took a placebo pill and Garcinia cambogia. Despite the popularity of Garcinia cambogia, it is challenging to monitor how successful supplements comprising it are. And clinical trials have shown it is not dangerous to take Garcinia cambogia extract the span of the studies, for 12 weeks at least by mouth —. Garcinia cambogia has side effects - it may lower a person's blood sugar , so it can interact with diabetes treatments.